OUAI Good Genes vs A+ Serum: Which Resurfacing Treatment Should You Choose?
By OUAI | Published: 2026-08-02
Category: Comparisons
Compare OUAI Good Genes Glycolic Acid Treatment and A+ High-Dose Retinoid Serum to find the best resurfacing treatment for your skin type and concerns.
When it comes to achieving smoother, brighter, and more youthful-looking skin, resurfacing treatments are a game-changer. OUAI offers two powerhouse options: the Good Genes Glycolic Acid Treatment and the A+ High-Dose Retinoid Serum. Both are designed to exfoliate and renew the skin, but they work in fundamentally different ways. Choosing between them depends on your skin type, concerns, and tolerance for active ingredients.

In this comparison, we'll break down the key differences between these two OUAI resurfacing treatments, including how they work, who they're best for, and how to incorporate them into your routine. By the end, you'll know exactly which one deserves a spot on your shelf.
How Good Genes Glycolic Acid Treatment Works
Good Genes is a leave-on exfoliating treatment powered by glycolic acid, an alpha hydroxy acid (AHA) derived from sugarcane. Glycolic acid has the smallest molecule size among AHAs, allowing it to penetrate deeply into the skin to dissolve the bonds between dead skin cells. This gentle yet effective exfoliation reveals fresh, radiant skin underneath while also stimulating collagen production over time.
This treatment is ideal for those looking to address dullness, uneven texture, and fine lines. It works on the surface level, making it a great option for beginners to chemical exfoliation or those with sensitive skin who cannot tolerate stronger actives like retinoids. Good Genes also contains soothing ingredients to minimize irritation, making it a reliable choice for regular use.
- Best for: dry, dull, or uneven skin; first-time exfoliator users
- Use at night, 2-3 times a week, and always follow with sunscreen in the morning
How A+ High-Dose Retinoid Serum Works
A+ High-Dose Retinoid Serum is a potent anti-aging treatment that combines retinoid and bakuchiol, a plant-based alternative to retinol. Retinoids work by accelerating cell turnover, which helps to unclog pores, fade dark spots, and smooth fine lines and wrinkles. The addition of bakuchiol helps to boost the efficacy while reducing potential irritation, making it a more tolerable retinoid option.
This serum targets deeper skin concerns such as acne, hyperpigmentation, and loss of elasticity. It is more powerful than Good Genes, but it also requires a period of adjustment. If you're new to retinoids, you'll need to start slowly, using it just once or twice a week and gradually increasing frequency as your skin builds tolerance.
- Best for: acne-prone, aging, or sun-damaged skin; experienced active users
- Use at night only, start with 1-2 times per week, and never mix with other strong actives
Key Differences: Glycolic Acid vs Retinoid
The main difference lies in how they exfoliate. Glycolic acid works on the surface, loosening dead skin cells, while retinoids work deeper by speeding up the skin's natural renewal process. This means Good Genes delivers immediate radiance and smoother texture, while A+ offers long-term anti-aging benefits like reduced wrinkles and improved firmness.
In terms of irritation potential, retinoids are generally more irritating and require a gradual introduction. Glycolic acid can also cause stinging if overused, but it is often better tolerated by sensitive skin. Your choice should depend on your primary concern: if you want instant glow, go with Good Genes; if you're in it for the long haul, A+ is your match.
- Good Genes: immediate results, surface-level exfoliation, suitable for all skin types including sensitive
- A+ Serum: long-term results, deep cell turnover, best for normal to oily skin that can handle stronger actives
Can You Use Both Together?
Yes, you can use both, but not on the same night. Many skincare enthusiasts alternate them: use Good Genes one night and A+ the next, or use Good Genes on nights when you're not using A+. This allows you to enjoy the immediate smoothing benefits of glycolic acid while reaping the long-term anti-aging rewards of the retinoid.
If you're new to these actives, start with just one to see how your skin reacts. Once your skin has built tolerance, you can introduce the other. Always listen to your skin and adjust frequency if you experience excessive dryness, redness, or peeling.
- Alternate nights: Good Genes on Monday, A+ on Tuesday, and so on
- Always apply to clean, dry skin and follow with a moisturizer
Ultimately, the best resurfacing treatment from OUAI depends on your skin goals and tolerance. If you want immediate radiance and gentle exfoliation, the Good Genes Glycolic Acid Treatment is your go-to. If you're seeking powerful anti-aging benefits and are willing to commit to a retinoid routine, the A+ High-Dose Retinoid Serum is worth the investment. For a balanced approach, consider alternating both to get the best of both worlds. Explore the Good Genes Glycolic Acid Treatment and A+ High-Dose Retinoid Serum at OUAI to start your journey to smoother, more luminous skin.



